Punicalagins-A Large Polyphenol Compounds Found in Pomegranates: A Therapeutic Review
Punicalagins are tannins, large polyphenol compounds that are isomers of 2, 3-(S)-hexahydroxydipehnoyl-4, 6-(S, S)-gallagyl-D-glucose, hydrolysable tannins with a molecular weight of 1084. They are found in forms α and β in pomegranates. Punicalagins are the largest molecule found intact in rat plasma after oral ingestion and were found to show no toxic effects in rats that were given a 6% diet of punicalagins for 37 days. Punicalagins are also found to be the major component responsible for pomegranate juice’s antioxidant and health benefits. Punicalagins are water-soluble and have high bioavailability. They ae known to hydrolyze into smaller polyphenols such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells. A study in Taiwan showed that α punicalagin shows potential as strong cancer suppressors. Compounds found only in pomegranate called punicalagins are shown to benefit the heart and blood vessels. Punicalagins are the major component responsible for pomegranate’s antioxidant and health benefits. They not only lower cholesterol, but also lower blood pressure and increase the speed at which heart blockages (atherosclerosis) melt away. The aim of present article is to provide in depth knowledge about Punicalagins, their chemical and biological profile as well as their role in prevention of certain dreadful disease such as cancer as well as various cardiac disorders.