Anti-cancer Activity of Noni Fruit Juice Against Tumors in Mice

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Noni fruit juice is one of the most popular traditional medicines among native Polynesian islanders in South Pacific Ocean. They use it for diabetes, high blood pressure, cancer, injury, arthritis, digestive distress, arteriosclerosis, pain relief, senility etc. We have confirmed the antitumor potential at animal level that noni fruit juice could inhibit murine tumor growth with a definite curative potential.

The first presentation was in 1992, at the 83rd annual meeting of American Association of Cancer Research at San Diego, CA: Antitumor Activity of Morinda citrifolia on Intraperitineally implanted Lewis Lung Carcinoma in Mice (Proc. Am. Soc. Cancer Res. 33, 515, 1992). Then, after two presentations and the brief publication (Proc. West. Pharmacol. Soc. 37, 145, 1994 and 39, 7, 1996), we published a full paper in 1999: An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity (Phytother. Res. 13, 380-387, 1999). Now, we have just submitted the second full-paper to Phytotherapy Research, entitled “ Antitumor potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) on sarcoma 180 ascites tumor in mice.”

Noni fruit juice is not cytotoxic in cell cultures (Lewis lung carcinoma cell line, Sarcoma 180 cells, human KB carcinoma cell line, or normal NIH/3T3 and BALB/3T3 cell lines), but the juice can indirectly kill the cancer cells via activation of the cellular immune system involving macrophages, natural killer cells and T cells. Therefore, noni fruit juice is one the powerful antitumor immunostimulators of plant food origin without having toxicity.

Eiichi Furusawa
Proceedings of the 2002 Hawai‘i Noni Conference